Amitriptyline interactions on FDA labels
These are pairs with Amitriptyline where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Amitriptyline; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Open Amitriptyline in the desk
Avoid together
- Amitriptyline and Isocarboxazid
Why this grade
Marplan (isocarboxazid) label, Contraindications
The Marplan (isocarboxazid) label lists this combination under Contraindications. CONTRAINDICATIONS: "Marplan should not be administered together with, or in close proximity to, other MAO inhibitors or dibenzazepine-related entities … Amitriptyline HCL" Named in the label: "Amitriptyline HCL" Retrieved from DailyMed 2026-10-19.
Marplan (isocarboxazid) label on DailyMed, for Amitriptyline and Isocarboxazid
Enzyme roles on the desk
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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