Drug pairs checked against FDA label text

Drug pairs where an FDA label names a specific interaction, each with the label's own wording and a link to the source. Open any pair in the desk to see it alongside other drugs. Educational reference only. Not FDA-cleared. The Prescribing Information governs. A pair that isn't listed here hasn't been cleared as safe; it just isn't on this list.

• Alosetron and Fluvoxamine · Avoid together
• Amphetamine and Linezolid · Avoid together
• Amphetamine and Methylene blue · Avoid together
• Apixaban and Rifampin · Serious concern
• Apomorphine and Alosetron · Avoid together
• Apomorphine and Dolasetron · Avoid together
• Apomorphine and Granisetron · Avoid together
• Apomorphine and Ondansetron · Avoid together
• Apomorphine and Palonosetron · Avoid together
• Atazanavir and Alfuzosin · Avoid together
• Atazanavir and Apalutamide · Avoid together
• Atazanavir and Carbamazepine · Avoid together
• Atazanavir–cobicistat and Alfuzosin · Avoid together
• Atazanavir–cobicistat and Apalutamide · Avoid together
• Atazanavir–cobicistat and Carbamazepine · Avoid together
• Atazanavir–cobicistat and Dihydroergotamine · Avoid together
• Atazanavir–cobicistat and Dronedarone · Avoid together
• Atazanavir–cobicistat and Drospirenone · Avoid together
• Atazanavir–cobicistat and Encorafenib · Avoid together
• Atazanavir–cobicistat and Ergotamine · Avoid together
• Atazanavir–cobicistat and Ethinyl estradiol (OCP) · Avoid together
• Atazanavir–cobicistat and Glecaprevir–pibrentasvir · Avoid together
• Atazanavir–cobicistat and Grazoprevir–elbasvir · Avoid together
• Atazanavir–cobicistat and Irinotecan · Avoid together
• Atazanavir–cobicistat and Ivosidenib · Avoid together
• Atazanavir–cobicistat and Lovastatin · Avoid together
• Atazanavir–cobicistat and Lurasidone · Avoid together
• Atazanavir–cobicistat and Methylergonovine · Avoid together
• Atazanavir–cobicistat and Midazolam · Avoid together
• Atazanavir–cobicistat and Nevirapine · Avoid together
• Atazanavir–cobicistat and Phenobarbital · Avoid together
• Atazanavir–cobicistat and Phenytoin · Avoid together
• Atazanavir–cobicistat and Pimozide · Avoid together
• Atazanavir–cobicistat and Ranolazine · Avoid together
• Atazanavir–cobicistat and Rifampin · Avoid together
• Atazanavir–cobicistat and Sildenafil (PAH) · Avoid together
• Atazanavir–cobicistat and Simvastatin · Avoid together
• Atazanavir–cobicistat and St. John's wort · Avoid together
• Atazanavir–cobicistat and Triazolam · Avoid together
• Atazanavir and Dihydroergotamine · Avoid together
• Atazanavir and Encorafenib · Avoid together
• Atazanavir and Ergotamine · Avoid together
• Atazanavir and Glecaprevir–pibrentasvir · Avoid together
• Atazanavir and Grazoprevir–elbasvir · Avoid together
• Atazanavir and Irinotecan · Avoid together
• Atazanavir and Ivosidenib · Avoid together
• Atazanavir and Lovastatin · Avoid together
• Atazanavir and Methylergonovine · Avoid together
• Atazanavir and Midazolam · Avoid together
• Atazanavir and Nevirapine · Avoid together
• Atazanavir and Phenobarbital · Avoid together
• Atazanavir and Phenytoin · Avoid together
• Atazanavir and Pimozide · Avoid together
• Atazanavir and Sildenafil (PAH) · Avoid together
• Atazanavir and Simvastatin · Avoid together
• Atazanavir and St. John's wort · Avoid together
• Atazanavir and Triazolam · Avoid together
• Bictegravir and Dofetilide · Avoid together
• Bictegravir–lenacapavir and Dofetilide · Avoid together
• Bictegravir and Rifampin · Avoid together
• Bosentan and Cyclosporine · Avoid together
• Bosentan and Glyburide · Avoid together
• Buprenorphine and Alprazolam · Serious concern
• Buprenorphine and Atazanavir · Serious concern
• Buprenorphine and Ethanol · Serious concern
• Buprenorphine and Ketoconazole · Serious concern
• Buprenorphine and Phenelzine · Serious concern
• Buprenorphine and Pregabalin · Serious concern
• Buprenorphine and Rifampin · Serious concern
• Bupropion and Linezolid · Avoid together
• Bupropion and Methylene blue · Avoid together
• Buspirone and Linezolid · Avoid together
• Buspirone and Methylene blue · Avoid together
• Carbamazepine and Nefazodone · Avoid together
• Citalopram and Linezolid · Avoid together
• Citalopram and Methylene blue · Avoid together
• Clarithromycin and Dihydroergotamine · Avoid together
• Clarithromycin and Ergotamine · Avoid together
• Clarithromycin and Lurasidone · Avoid together
• Clomipramine and Linezolid · Avoid together
• Clomipramine and Methylene blue · Avoid together
• Clopidogrel and Esomeprazole · Serious concern
• Clopidogrel and Omeprazole · Serious concern
• Naltrexone–bupropion and Bupropion · Avoid together
• Naltrexone–bupropion and Bupropion XL · Avoid together
• Darunavir and Alfuzosin · Avoid together
• Darunavir–cobicistat and Alfuzosin · Avoid together
• Darunavir–cobicistat and Carbamazepine · Avoid together
• Darunavir–cobicistat and Dihydroergotamine · Avoid together
• Darunavir–cobicistat and Dronedarone · Avoid together
• Darunavir–cobicistat and Ergotamine · Avoid together
• Darunavir–cobicistat and Grazoprevir–elbasvir · Avoid together
• Darunavir–cobicistat and Ivabradine · Avoid together
• Darunavir–cobicistat and Lovastatin · Avoid together
• Darunavir–cobicistat and Lurasidone · Avoid together
• Darunavir–cobicistat and Methylergonovine · Avoid together
• Darunavir–cobicistat and Midazolam · Avoid together
• Darunavir–cobicistat and Naloxegol · Avoid together
• Darunavir–cobicistat and Phenobarbital · Avoid together
• Darunavir–cobicistat and Phenytoin · Avoid together
• Darunavir–cobicistat and Pimozide · Avoid together
• Darunavir–cobicistat and Ranolazine · Avoid together
• Darunavir–cobicistat and Rifampin · Avoid together
• Darunavir–cobicistat and Sildenafil (PAH) · Avoid together
• Darunavir–cobicistat and Simvastatin · Avoid together
• Darunavir–cobicistat and St. John's wort · Avoid together
• Darunavir–cobicistat and Triazolam · Avoid together
• Darunavir and Dihydroergotamine · Avoid together
• Darunavir and Dronedarone · Avoid together
• Darunavir and Ergotamine · Avoid together
• Darunavir and Grazoprevir–elbasvir · Avoid together
• Darunavir and Ivabradine · Avoid together
• Darunavir and Lovastatin · Avoid together
• Darunavir and Lurasidone · Avoid together
• Darunavir and Methylergonovine · Avoid together
• Darunavir and Midazolam · Avoid together
• Darunavir and Naloxegol · Avoid together
• Darunavir and Pimozide · Avoid together
• Darunavir and Ranolazine · Avoid together
• Darunavir and Rifampin · Avoid together
• Darunavir and Sildenafil (PAH) · Avoid together
• Darunavir and Simvastatin · Avoid together
• Darunavir and St. John's wort · Avoid together
• Darunavir and Triazolam · Avoid together
• Desvenlafaxine and Linezolid · Avoid together
• Desvenlafaxine and Methylene blue · Avoid together
• Deutetrabenazine and Valbenazine · Avoid together
• Dihydroergotamine and Erythromycin · Avoid together
• Dihydroergotamine and Ketoconazole · Avoid together
• Dofetilide and Cimetidine · Avoid together
• Dofetilide and Hydrochlorothiazide · Avoid together
• Dofetilide and Ketoconazole · Avoid together
• Dofetilide and Trimethoprim–sulfamethoxazole · Avoid together
• Dofetilide and Verapamil · Avoid together
• Dolutegravir and Dofetilide · Avoid together
• Dronedarone and Clarithromycin · Avoid together
• Dronedarone and Erythromycin · Avoid together
• Dronedarone and Ketoconazole · Avoid together
• Dronedarone and Nefazodone · Avoid together
• Dronedarone and Telithromycin · Avoid together
• Dronedarone and Voriconazole · Avoid together
• Duloxetine and Linezolid · Avoid together
• Duloxetine and Methylene blue · Avoid together
• Eletriptan and Clarithromycin · Avoid together
• Eletriptan and Itraconazole · Avoid together
• Eletriptan and Ketoconazole · Avoid together
• Eletriptan and Nefazodone · Avoid together
• Eletriptan and Ritonavir · Avoid together
• Eplerenone and Clarithromycin · Avoid together
• Eplerenone and Ketoconazole · Avoid together
• Eplerenone and Nefazodone · Avoid together
• Eplerenone and Ritonavir · Avoid together
• Ergotamine and Erythromycin · Avoid together
• Ergotamine and Ketoconazole · Avoid together
• Ergotamine and Ritonavir · Avoid together
• Escitalopram and Linezolid · Avoid together
• Escitalopram and Methylene blue · Avoid together
• Esketamine and Alprazolam · Serious concern
• Esketamine and Amphetamine · Use care
• Esketamine and Ethanol · Serious concern
• Esketamine and Methylphenidate · Use care
• Esketamine and Phenelzine · Use care
• Fluoxetine and Linezolid · Avoid together
• Fluoxetine and Methylene blue · Avoid together
• Fluvoxamine and Linezolid · Avoid together
• Fluvoxamine and Methylene blue · Avoid together
• Glecaprevir–pibrentasvir and Rifampin · Avoid together
• Isocarboxazid and Buspirone · Avoid together
• Isocarboxazid and Dextromethorphan · Avoid together
• Itraconazole and Avanafil · Avoid together
• Itraconazole and Dihydroergotamine · Avoid together
• Itraconazole and Disopyramide · Avoid together
• Itraconazole and Dofetilide · Avoid together
• Itraconazole and Dronedarone · Avoid together
• Itraconazole and Eplerenone · Avoid together
• Itraconazole and Ergotamine · Avoid together
• Itraconazole and Felodipine · Avoid together
• Itraconazole and Finerenone · Avoid together
• Itraconazole and Irinotecan · Avoid together
• Itraconazole and Isavuconazonium · Avoid together
• Itraconazole and Ivabradine · Avoid together
• Itraconazole and Lovastatin · Avoid together
• Itraconazole and Lurasidone · Avoid together
• Itraconazole and Methadone · Avoid together
• Itraconazole and Methylergonovine · Avoid together
• Itraconazole and Midazolam · Avoid together
• Itraconazole and Naloxegol · Avoid together
• Itraconazole and Nisoldipine · Avoid together
• Itraconazole and Pimozide · Avoid together
• Itraconazole and Quinidine · Avoid together
• Itraconazole and Ranolazine · Avoid together
• Itraconazole and Ticagrelor · Avoid together
• Itraconazole and Triazolam · Avoid together
• Itraconazole and Voclosporin · Avoid together
• Ivabradine and Clarithromycin · Avoid together
• Ketamine and Ethanol · Serious concern
• Ketamine and Lorazepam · Serious concern
• Ketamine and Theophylline · Use care
• Lemborexant and Itraconazole · Serious concern
• Levoketoconazole and Bosutinib · Avoid together
• Levoketoconazole and Clarithromycin · Avoid together
• Levoketoconazole and Cobimetinib · Avoid together
• Levoketoconazole and Crizotinib · Avoid together
• Levoketoconazole and Disopyramide · Avoid together
• Levoketoconazole and Dofetilide · Avoid together
• Levoketoconazole and Dronedarone · Avoid together
• Levoketoconazole and Ivabradine · Avoid together
• Levoketoconazole and Methadone · Avoid together
• Levoketoconazole and Midostaurin · Avoid together
• Levoketoconazole and Nicardipine · Avoid together
• Levoketoconazole and Pimozide · Avoid together
• Levoketoconazole and Quinidine · Avoid together
• Levoketoconazole and Ranolazine · Avoid together
• Levomilnacipran and Linezolid · Avoid together
• Levomilnacipran and Methylene blue · Avoid together
• Linezolid and Isocarboxazid · Avoid together
• Linezolid and Phenelzine · Avoid together
• Lisdexamfetamine and Linezolid · Avoid together
• Lisdexamfetamine and Methylene blue · Avoid together
• Lonafarnib and Atorvastatin · Avoid together
• Lonafarnib and Lovastatin · Avoid together
• Lonafarnib and Midazolam · Avoid together
• Lonafarnib and Simvastatin · Avoid together
• Lopinavir/ritonavir and Alfuzosin · Avoid together
• Lopinavir/ritonavir and Apalutamide · Avoid together
• Lopinavir/ritonavir and Dihydroergotamine · Avoid together
• Lopinavir/ritonavir and Dronedarone · Avoid together
• Lopinavir/ritonavir and Ergotamine · Avoid together
• Lopinavir/ritonavir and Grazoprevir–elbasvir · Avoid together
• Lopinavir/ritonavir and Lovastatin · Avoid together
• Lopinavir/ritonavir and Lurasidone · Avoid together
• Lopinavir/ritonavir and Methylergonovine · Avoid together
• Lopinavir/ritonavir and Midazolam · Avoid together
• Lopinavir/ritonavir and Pimozide · Avoid together
• Lopinavir/ritonavir and Ranolazine · Avoid together
• Lopinavir/ritonavir and Rifampin · Avoid together
• Lopinavir/ritonavir and Sildenafil (PAH) · Avoid together
• Lopinavir/ritonavir and Simvastatin · Avoid together
• Lopinavir/ritonavir and St. John's wort · Avoid together
• Lopinavir/ritonavir and Suzetrigine · Avoid together
• Lopinavir/ritonavir and Triazolam · Avoid together
• Lovastatin and Clarithromycin · Avoid together
• Lurasidone and Carbamazepine · Avoid together
• Lurasidone and Ketoconazole · Avoid together
• Lurasidone and Phenytoin · Avoid together
• Lurasidone and Rifampin · Avoid together
• Lurasidone and St. John's wort · Avoid together
• Lurasidone and Voriconazole · Avoid together
• Methadone and Alprazolam · Serious concern
• Methadone and Buprenorphine · Serious concern
• Methadone and Carbamazepine · Serious concern
• Methadone and Ethanol · Serious concern
• Methadone and Fluconazole · Serious concern
• Methadone and Gabapentin · Serious concern
• Methadone and Ketoconazole · Serious concern
• Methadone and Ondansetron · Serious concern
• Methadone and Rifampin · Serious concern
• Methadone and Sotalol · Serious concern
• Methadone and Zidovudine · Use care
• Mifepristone and Cyclosporine · Avoid together
• Mifepristone and Dihydroergotamine · Avoid together
• Mifepristone and Ergotamine · Avoid together
• Mifepristone and Fentanyl · Avoid together
• Mifepristone and Lovastatin · Avoid together
• Mifepristone and Pimozide · Avoid together
• Mifepristone and Quinidine · Avoid together
• Mifepristone and Simvastatin · Avoid together
• Mifepristone and Sirolimus · Avoid together
• Mifepristone and Tacrolimus · Avoid together
• Milnacipran and Linezolid · Avoid together
• Milnacipran and Methylene blue · Avoid together
• Mirtazapine and Linezolid · Avoid together
• Mirtazapine and Methylene blue · Avoid together
• Naloxegol and Clarithromycin · Avoid together
• Naloxegol and Ketoconazole · Avoid together
• Naltrexone and Buprenorphine · Avoid together
• Naltrexone–bupropion and Buprenorphine · Avoid together
• Naltrexone–bupropion and Linezolid · Avoid together
• Naltrexone–bupropion and Methadone · Avoid together
• Naltrexone–bupropion and Methylene blue · Avoid together
• Naltrexone and Hydrocodone · Avoid together
• Naltrexone and Methadone · Avoid together
• Naltrexone and Oxycodone · Avoid together
• Paroxetine and Linezolid · Avoid together
• Paroxetine and Methylene blue · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Alfuzosin · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Amiodarone · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Apalutamide · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Carbamazepine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Dihydroergotamine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Dronedarone · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Eletriptan · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Enzalutamide · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Eplerenone · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Ergotamine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Finerenone · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Flecainide · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Ivabradine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Lovastatin · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Lumacaftor–ivacaftor · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Lurasidone · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Methylergonovine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Midazolam · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Naloxegol · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Phenobarbital · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Phenytoin · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Pimozide · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Primidone · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Propafenone · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Quinidine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Ranolazine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Rifampin · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Rifapentine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Sildenafil (PAH) · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Silodosin · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Simvastatin · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and St. John's wort · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Suzetrigine · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Tolvaptan · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Triazolam · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Ubrogepant · Avoid together
• Paxlovid (nirmatrelvir/ritonavir) and Voclosporin · Avoid together
• Phenelzine and Amphetamine · Avoid together
• Phenelzine and Buspirone · Avoid together
• Phenelzine and Citalopram · Avoid together
• Phenelzine and Cocaine · Avoid together
• Phenelzine and Dextromethorphan · Avoid together
• Phenelzine and Dopamine · Avoid together
• Phenelzine and Epinephrine · Avoid together
• Phenelzine and Fluoxetine · Avoid together
• Phenelzine and Fluvoxamine · Avoid together
• Phenelzine and Isocarboxazid · Avoid together
• Phenelzine and Meperidine · Avoid together
• Phenelzine and Methadone · Avoid together
• Phenelzine and Methylphenidate · Avoid together
• Phenelzine and Norepinephrine · Avoid together
• Phenelzine and Paroxetine · Avoid together
• Phenelzine and Sertraline · Avoid together
• Phenelzine and Tramadol · Avoid together
• Phenelzine and Tranylcypromine · Avoid together
• Phenelzine and Venlafaxine · Avoid together
• Pimozide and Azithromycin · Avoid together
• Pimozide and Citalopram · Avoid together
• Pimozide and Clarithromycin · Avoid together
• Pimozide and Erythromycin · Avoid together
• Pimozide and Escitalopram · Avoid together
• Pimozide and Fluoxetine · Avoid together
• Pimozide and Fluvoxamine · Avoid together
• Pimozide and Ketoconazole · Avoid together
• Pimozide and Nefazodone · Avoid together
• Pimozide and Paroxetine · Avoid together
• Pimozide and Sertraline · Avoid together
• Posaconazole and Atorvastatin · Avoid together
• Posaconazole and Dihydroergotamine · Avoid together
• Posaconazole and Ergotamine · Avoid together
• Posaconazole and Lovastatin · Avoid together
• Posaconazole and Pimozide · Avoid together
• Posaconazole and Quinidine · Avoid together
• Posaconazole and Simvastatin · Avoid together
• Posaconazole and Sirolimus · Avoid together
• Ramelteon and Fluvoxamine · Avoid together
• Ranolazine and Clarithromycin · Avoid together
• Ranolazine and Ketoconazole · Avoid together
• Ranolazine and Phenobarbital · Avoid together
• Ranolazine and Primidone · Avoid together
• Ranolazine and Rifampin · Avoid together
• Ranolazine and St. John's wort · Avoid together
• Rasagiline and Cyclobenzaprine · Avoid together
• Rasagiline and Meperidine · Avoid together
• Rasagiline and Methadone · Avoid together
• Rasagiline and St. John's wort · Avoid together
• Rasagiline and Tramadol · Avoid together
• Rifampin and Atazanavir · Avoid together
• Rilpivirine and Carbamazepine · Avoid together
• Rilpivirine and Esomeprazole · Avoid together
• Rilpivirine and Lansoprazole · Avoid together
• Rilpivirine and Omeprazole · Avoid together
• Rilpivirine and Oxcarbazepine · Avoid together
• Rilpivirine and Pantoprazole · Avoid together
• Rilpivirine and Phenobarbital · Avoid together
• Rilpivirine and Phenytoin · Avoid together
• Rilpivirine and Rabeprazole · Avoid together
• Rilpivirine and Rifampin · Avoid together
• Rilpivirine and Rifapentine · Avoid together
• Rilpivirine and St. John's wort · Avoid together
• Riociguat and Dipyridamole · Avoid together
• Riociguat and Sildenafil · Avoid together
• Riociguat and Tadalafil · Avoid together
• Riociguat and Theophylline · Avoid together
• Riociguat and Vardenafil · Avoid together
• Ritonavir and Alfuzosin · Avoid together
• Ritonavir and Amiodarone · Avoid together
• Ritonavir and Apalutamide · Avoid together
• Ritonavir and Dihydroergotamine · Avoid together
• Ritonavir and Dronedarone · Avoid together
• Ritonavir and Flecainide · Avoid together
• Ritonavir and Lovastatin · Avoid together
• Ritonavir and Lurasidone · Avoid together
• Ritonavir and Methylergonovine · Avoid together
• Ritonavir and Midazolam · Avoid together
• Ritonavir and Pimozide · Avoid together
• Ritonavir and Propafenone · Avoid together
• Ritonavir and Quinidine · Avoid together
• Ritonavir and Ranolazine · Avoid together
• Ritonavir and Sildenafil (PAH) · Avoid together
• Ritonavir and St. John's wort · Avoid together
• Ritonavir and Suzetrigine · Avoid together
• Ritonavir and Triazolam · Avoid together
• Rivaroxaban and Ketoconazole · Serious concern
• Safinamide and Amphetamine · Avoid together
• Safinamide and Cyclobenzaprine · Avoid together
• Safinamide and Linezolid · Avoid together
• Safinamide and Meperidine · Avoid together
• Safinamide and Methadone · Avoid together
• Safinamide and Methylphenidate · Avoid together
• Safinamide and St. John's wort · Avoid together
• Safinamide and Tramadol · Avoid together
• Selegiline and Meperidine · Avoid together
• Sertraline and Linezolid · Avoid together
• Sertraline and Methylene blue · Avoid together
• Sildenafil (PAH) and Riociguat · Avoid together
• Simvastatin and Clarithromycin · Avoid together
• Simvastatin and Itraconazole · Avoid together
• Simvastatin and Ritonavir · Avoid together
• Sodium oxybate and Ethanol · Avoid together
• Sodium oxybate and Zolpidem · Avoid together
• Sofosbuvir–velpatasvir–voxilaprevir and Rifampin · Avoid together
• Suvorexant and Ketoconazole · Serious concern
• Tetrabenazine and Deutetrabenazine · Avoid together
• Tetrabenazine and Valbenazine · Avoid together
• Thioridazine and Abiraterone · Avoid together
• Thioridazine and Cinacalcet · Avoid together
• Thioridazine and Fluoxetine · Avoid together
• Thioridazine and Fluvoxamine · Avoid together
• Thioridazine and Paroxetine · Avoid together
• Thioridazine and Pindolol · Avoid together
• Ticagrelor and Ketoconazole · Serious concern
• Tizanidine and Ciprofloxacin · Avoid together
• Tizanidine and Fluvoxamine · Avoid together
• Tranylcypromine and Buspirone · Avoid together
• Tranylcypromine and Cyclobenzaprine · Avoid together
• Tranylcypromine and Meperidine · Avoid together
• Tranylcypromine and Milnacipran · Avoid together
• Tranylcypromine and Nefazodone · Avoid together
• Tranylcypromine and Rasagiline · Avoid together
• Tranylcypromine and Tapentadol · Avoid together
• Tranylcypromine and Trazodone · Avoid together
• Tranylcypromine and Vilazodone · Avoid together
• Tranylcypromine and Vortioxetine · Avoid together
• Trazodone and Linezolid · Avoid together
• Trazodone and Methylene blue · Avoid together
• Triazolam and Ketoconazole · Avoid together
• Triazolam and Nefazodone · Avoid together
• Venlafaxine and Linezolid · Avoid together
• Venlafaxine and Methylene blue · Avoid together
• Vilazodone and Linezolid · Avoid together
• Vilazodone and Methylene blue · Avoid together
• Voriconazole and Rifampin · Avoid together
• Vortioxetine and Linezolid · Avoid together
• Vortioxetine and Methylene blue · Avoid together
• Ziprasidone and Amiodarone · Avoid together
• Ziprasidone and Arsenic trioxide · Avoid together
• Ziprasidone and Chlorpromazine · Avoid together
• Ziprasidone and Dofetilide · Avoid together
• Ziprasidone and Dolasetron · Avoid together
• Ziprasidone and Dronedarone · Avoid together
• Ziprasidone and Droperidol · Avoid together
• Ziprasidone and Gatifloxacin · Avoid together
• Ziprasidone and Ibutilide · Avoid together
• Ziprasidone and Isocarboxazid · Avoid together
• Ziprasidone and Linezolid · Avoid together
• Ziprasidone and Mefloquine · Avoid together
• Ziprasidone and Methylene blue · Avoid together
• Ziprasidone and Moclobemide · Avoid together
• Ziprasidone and Moxifloxacin · Avoid together
• Ziprasidone and Phenelzine · Avoid together
• Ziprasidone and Pimozide · Avoid together
• Ziprasidone and Procainamide · Avoid together
• Ziprasidone and Quinidine · Avoid together
• Ziprasidone and Rasagiline · Avoid together
• Ziprasidone and Safinamide · Avoid together
• Ziprasidone and Selegiline · Avoid together
• Ziprasidone and Sotalol · Avoid together
• Ziprasidone and Thioridazine · Avoid together
• Ziprasidone and Tranylcypromine · Avoid together

By drug

• Abiraterone
• Alfuzosin
• Alosetron
• Alprazolam
• Amiodarone
• Amphetamine
• Apalutamide
• Apixaban
• Apomorphine
• Arsenic trioxide
• Atazanavir
• Atorvastatin
• Avanafil
• Azithromycin
• Bactrim (trimethoprim–sulfamethoxazole)
• Bictegravir
• Bixlenvo (bictegravir–lenacapavir)
• Bosentan
• Bosutinib
• Buprenorphine
• Bupropion
• Bupropion XL
• Buspirone
• Carbamazepine
• Chlorpromazine
• Cimetidine
• Cinacalcet
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clomipramine
• Clopidogrel
• Cobimetinib
• Cocaine
• Contrave (naltrexone–bupropion)
• Crizotinib
• Cyclobenzaprine
• Cyclosporine
• Darunavir
• Desvenlafaxine
• Deutetrabenazine
• Dextromethorphan
• Dihydroergotamine
• Dipyridamole
• Disopyramide
• Dofetilide
• Dolasetron
• Dolutegravir
• Dopamine
• Dronedarone
• Droperidol
• Drospirenone
• Duloxetine
• Eletriptan
• Encorafenib
• Enzalutamide
• Epinephrine
• Eplerenone
• Ergotamine
• Erythromycin
• Escitalopram
• Esketamine
• Esomeprazole
• Ethanol
• Ethinyl estradiol (OCP)
• Evotaz (atazanavir–cobicistat)
• Felodipine
• Fentanyl
• Finerenone
• Flecainide
• Fluconazole
• Fluoxetine
• Fluvoxamine
• Gabapentin
• Gatifloxacin
• Glyburide
• Granisetron
• Hydrochlorothiazide
• Hydrocodone
• Ibutilide
• Irinotecan
• Isavuconazonium
• Isocarboxazid
• Itraconazole
• Ivabradine
• Ivosidenib
• Kaletra (lopinavir/ritonavir)
• Ketamine
• Ketoconazole
• Lansoprazole
• Lemborexant
• Levoketoconazole
• Levomilnacipran
• Linezolid
• Lisdexamfetamine
• Lonafarnib
• Lorazepam
• Lovastatin
• Lurasidone
• Mavyret (glecaprevir–pibrentasvir)
• Mefloquine
• Meperidine
• Methadone
• Methylene blue
• Methylergonovine
• Methylphenidate
• Midazolam
• Midostaurin
• Mifepristone
• Milnacipran
• Mirtazapine
• Moclobemide
• Moxifloxacin
• Naloxegol
• Naltrexone
• Nefazodone
• Nevirapine
• Nicardipine
• Nisoldipine
• Norepinephrine
• Omeprazole
• Ondansetron
• Orkambi (lumacaftor–ivacaftor)
• Oxcarbazepine
• Oxycodone
• Palonosetron
• Pantoprazole
• Paroxetine
• Paxlovid (nirmatrelvir/ritonavir)
• Phenelzine
• Phenobarbital
• Phenytoin
• Pimozide
• Pindolol
• Posaconazole
• Pregabalin
• Prezcobix (darunavir–cobicistat)
• Primidone
• Procainamide
• Propafenone
• Quinidine
• Rabeprazole
• Ramelteon
• Ranolazine
• Rasagiline
• Rifampin
• Rifapentine
• Rilpivirine
• Riociguat
• Ritonavir
• Rivaroxaban
• Safinamide
• Selegiline
• Sertraline
• Sildenafil
• Sildenafil (PAH)
• Silodosin
• Simvastatin
• Sirolimus
• Sodium oxybate
• Sotalol
• St. John's wort
• Suvorexant
• Suzetrigine
• Tacrolimus
• Tadalafil
• Tapentadol
• Telithromycin
• Tetrabenazine
• Theophylline
• Thioridazine
• Ticagrelor
• Tizanidine
• Tolvaptan
• Tramadol
• Tranylcypromine
• Trazodone
• Triazolam
• Ubrogepant
• Valbenazine
• Vardenafil
• Venlafaxine
• Verapamil
• Vilazodone
• Voclosporin
• Voriconazole
• Vortioxetine
• Vosevi (sofosbuvir–velpatasvir–voxilaprevir)
• Zepatier (grazoprevir–elbasvir)
• Zidovudine
• Ziprasidone
• Zolpidem

By enzyme

• CYP1A2
• CYP2B6
• CYP2C8
• CYP2C9
• CYP2C19
• CYP2D6
• CYP2E1
• CYP3A4
• P-gp
• All enzymes

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Educational reference only. Not FDA-cleared. The Prescribing Information governs.