Irinotecan interactions on FDA labels
These are pairs with Irinotecan where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Irinotecan; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- Irinotecan and Atazanavir
Why this grade
Reyataz (atazanavir) label, Contraindications
The Reyataz (atazanavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS (Table 6): "Coadministration is contraindicated with, but not limited to, the following drugs" Named in the label: "Antineoplastics Apalutamide, encorafenib, irinotecan, ivosidenib" Retrieved from DailyMed 2026-10-02.
Open source - Irinotecan and Atazanavir–cobicistat
Why this grade
Evotaz (atazanavir/cobicistat) label, Contraindications
The Evotaz (atazanavir/cobicistat) label lists this combination under Contraindications. 4 CONTRAINDICATIONS (Table 1): "The concomitant use of EVOTAZ and the following drugs in Table 1, are contraindicated" Named in the label: "Antineoplastics apalutamide, encorafenib, irinotecan, ivosidenib" Retrieved from DailyMed 2026-10-02.
Open source - Irinotecan and Itraconazole
Why this grade
Sporanox (itraconazole) label, Contraindications
The Sporanox (itraconazole) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of a number of CYP3A4 substrates are contraindicated with SPORANOX®." Named in the label: "irinotecan" Retrieved from DailyMed 2026-10-02.
Open source
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
Drug and product names are trademarks of their owners and are used only to identify the products.