nelfinavir interactions on FDA labels
These are pairs with nelfinavir where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with nelfinavir; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- nelfinavir and Dihydroergotamine
Why this grade
Dihydroergotamine mesylate injection label, Contraindications
The Dihydroergotamine mesylate injection label lists this combination under Contraindications. CONTRAINDICATIONS: "The use of potent CYP3A4 inhibitors (i.e., ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is, therefore contraindicated" Named in the label: "nelfinavir" Retrieved from DailyMed 2026-10-12.
Dihydroergotamine mesylate injection label on DailyMed, for nelfinavir and Dihydroergotamine - nelfinavir and Eletriptan
Why this grade
Relpax (eletriptan) label, Contraindications
The Relpax (eletriptan) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Recent use (i.e., within at least 72 hours) of the following potent CYP3A4 inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, or nelfinavir" Named in the label: "nelfinavir" Retrieved from DailyMed 2026-10-12.
Relpax (eletriptan) label on DailyMed, for nelfinavir and Eletriptan - nelfinavir and Eplerenone
Why this grade
Inspra (eplerenone) label, Contraindications
The Inspra (eplerenone) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "INSPRA is contraindicated in all patients with: … concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)" Named in the label: "nelfinavir" Retrieved from DailyMed 2026-10-12.
Inspra (eplerenone) label on DailyMed, for nelfinavir and Eplerenone - nelfinavir and Ergotamine
Why this grade
Cafergot (ergotamine/caffeine) label, Contraindications
The Cafergot (ergotamine/caffeine) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of ergotamine with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) … ergotamine use is contraindicated with these drugs" Named in the label: "nelfinavir" Retrieved from DailyMed 2026-10-12.
Cafergot (ergotamine/caffeine) label on DailyMed, for nelfinavir and Ergotamine - nelfinavir and Ranolazine
Why this grade
Ranolazine extended-release label, Contraindications
The Ranolazine extended-release label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Ranolazine is contraindicated in patients: Taking strong inhibitors of CYP3A … Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin, nelfinavir)" Named in the label: "nelfinavir" Retrieved from DailyMed 2026-10-12.
Ranolazine extended-release label on DailyMed, for nelfinavir and Ranolazine
Enzyme roles on the desk
- CYP3A4 · strong inhibitor
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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