SAM-e interactions on FDA labels
These are pairs with SAM-e where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with SAM-e; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- SAM-e and Tranylcypromine
Why this grade
Parnate (tranylcypromine) label, Contraindications
The Parnate (tranylcypromine) label lists this combination under Contraindications. 4.1 Combination with Certain Drugs: "Concomitant use of PARNATE or use in rapid succession with the products in Table 1 is contraindicated … s-adenosyl-L-methionine (SAM-e)" Named in the label: "s-adenosyl-L-methionine (SAM-e)" Retrieved from DailyMed 2026-10-19.
Parnate (tranylcypromine) label on DailyMed, for SAM-e and Tranylcypromine
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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