All pairs

Alosetron and Fluvoxamine

Desk tier: Avoid together

Mechanism: strong CYP1A2 inhibition of clearance (↑ exposure)

“Concomitant administration of LOTRONEX with fluvoxamine is contraindicated.”
Lotronex (alosetron), section 4.3 Concomitant Use of Fluvoxamine. DailyMed label

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All pairs for Alosetron · Fluvoxamine

Enzyme behind this pair: CYP1A2

Educational reference only. Not FDA-cleared. The Prescribing Information governs.