All pairs

Apixaban and Rifampin

Desk tier: Serious concern

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“Avoid concomitant use of ELIQUIS with combined P-gp and strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin”
Eliquis (apixaban), section 7.2 Combined P-gp and Strong CYP3A4 Inducers. DailyMed label

Open this pair in the desk

All pairs for Apixaban · Rifampin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.