Apomorphine and Palonosetron

Desk tier: Avoid together

Mechanism: combined QT load (additive QT prolongation / TdP)

“APOKYN is contraindicated in patients: Using concomitant drugs of the 5HT 3 antagonist class including antiemetics (e.g., ondansetron, granisetron, dolasetron, palonosetron) and alosetron”

Apokyn (apomorphine), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Apomorphine · Palonosetron

Educational reference only. Not FDA-cleared. The Prescribing Information governs.