All pairs

Atazanavir and Phenobarbital

Desk tier: Avoid together

Mechanism: moderate CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“Coadministration is contraindicated with, but not limited to, the following drugs”
Reyataz (atazanavir), section 4 CONTRAINDICATIONS (Table 6). DailyMed label

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All pairs for Atazanavir · Phenobarbital

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.