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Bictegravir and Rifampin

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“BIKTARVY is contraindicated to be co-administered with: … rifampin due to decreased BIC plasma concentrations”
Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Bictegravir · Rifampin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.