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Bosentan and Cyclosporine

Desk tier: Avoid together

Mechanism: moderate CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“concomitant use of TRACLEER and cyclosporine A is contraindicated”
Tracleer (bosentan), section 4.2 Use with Cyclosporine A. DailyMed label

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All pairs for Bosentan · Cyclosporine

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.