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Bosentan and Glyburide

Desk tier: Avoid together

Mechanism: moderate CYP2C9 induction of clearance (↓ exposure / loss of efficacy)

“co-administration of glyburide and TRACLEER is contraindicated”
Tracleer (bosentan), section 4.3 Use with Glyburide. DailyMed label

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All pairs for Bosentan · Glyburide

Enzyme behind this pair: CYP2C9

Educational reference only. Not FDA-cleared. The Prescribing Information governs.