Buprenorphine and Alprazolam

Desk tier: Serious concern

Mechanism: opioid × benzodiazepine / Z-drug (respiratory depression)

“Concomitant use of buprenorphine and benzodiazepines and/or other CNS depressants … increases the risk of adverse reactions including overdose, respiratory depression, and death.”

Suboxone (buprenorphine/naloxone) film, section 5.3 Managing Risks from Concomitant Use of Benzodiazepines or Other CNS Depressants. DailyMed label

Open this pair in the desk

All pairs for Buprenorphine · Alprazolam

Educational reference only. Not FDA-cleared. The Prescribing Information governs.