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Buprenorphine and Atazanavir

Desk tier: Serious concern

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Symptoms of opioid excess have been found in post-marketing reports of patients receiving buprenorphine and atazanavir with and without ritonavir concomitantly.”
Suboxone (buprenorphine/naloxone) film, section 7 DRUG INTERACTIONS (Antiretrovirals: Protease inhibitors). DailyMed label

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All pairs for Buprenorphine · Atazanavir

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.