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Buprenorphine and Rifampin

Desk tier: Serious concern

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“The concomitant use of buprenorphine and CYP3A4 inducers can decrease the plasma concentration of buprenorphine”
Suboxone (buprenorphine/naloxone) film, section 7 DRUG INTERACTIONS (CYP3A4 Inducers). DailyMed label

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All pairs for Buprenorphine · Rifampin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.