Clarithromycin and Lurasidone

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“and lurasidone is contraindicated since it may result in an increase in lurasidone exposure”

Clarithromycin tablets, section 4 CONTRAINDICATIONS. DailyMed label

Why this grade

Clarithromycin tablets label, Contraindications

The Clarithromycin tablets label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "and lurasidone is contraindicated since it may result in an increase in lurasidone exposure" Retrieved from DailyMed 2026-10-02.

Open source

FDA interaction table

FDA's example-interaction table lists Clarithromycin as a strong CYP3A inhibitor, and Lurasidone as a sensitive CYP3A substrate. FDA grades the roles; the severity tier on this row is the desk's rule. Table content current as of 2026-05-29.

Open source

PMID 16007523

2005 Clin Infect Dis. Hung. 3A4/P-gp plus CKD. Colchicine is NTI.

Open source

Open this pair in the desk

All pairs for Clarithromycin · Lurasidone

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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