Naltrexone–bupropion and Bupropion

Desk tier: Avoid together

Mechanism: labeled contraindication (labeled contraindication)

“CONTRAVE is contraindicated in … Use of other bupropion-containing products (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN)”

Contrave (naltrexone/bupropion), section 4 CONTRAINDICATIONS. DailyMed label

Why this grade

Contrave (naltrexone/bupropion) label, Contraindications

The Contrave (naltrexone/bupropion) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "CONTRAVE is contraindicated in … Use of other bupropion-containing products (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN)" Named in the label: "WELLBUTRIN" Retrieved from DailyMed 2026-10-12.

Open source

PMID 32721035

2020 Clin Pharmacol Ther. Cicali. Phenoconversion is why a 2D6 NM on bupropion is not a 2D6 NM.

Open source

Open this pair in the desk

All pairs for Naltrexone–bupropion · Bupropion

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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