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Darunavir–cobicistat and Rifampin

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“Examples of drugs that are contraindicated for co-administration with PREZCOBIX”
Prezcobix (darunavir/cobicistat), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Darunavir–cobicistat · Rifampin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.