Dihydroergotamine and troleandomycin
Desk tier: Avoid together
Mechanism: labeled contraindication (labeled contraindication)
“The use of potent CYP3A4 inhibitors (i.e., ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is, therefore contraindicated”
Why this grade
Dihydroergotamine mesylate injection label, Contraindications
The Dihydroergotamine mesylate injection label lists this combination under Contraindications. CONTRAINDICATIONS: "The use of potent CYP3A4 inhibitors (i.e., ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is, therefore contraindicated" Named in the label: "troleandomycin" Retrieved from DailyMed 2026-10-12.
Dihydroergotamine mesylate injection label on DailyMedAll pairs for Dihydroergotamine · troleandomycin
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
Drug and product names are trademarks of their owners and are used only to identify the products.