Dronedarone and Voriconazole

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Concomitant use of strong CYP3A inhibitors, such as ketoconazole, itraconazole, voriconazole, cyclosporine, telithromycin, clarithromycin, nefazodone, and ritonavir”

Multaq (dronedarone), section 4 CONTRAINDICATIONS. DailyMed label

Why this grade

Multaq (dronedarone) label, Contraindications

The Multaq (dronedarone) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Concomitant use of strong CYP3A inhibitors, such as ketoconazole, itraconazole, voriconazole, cyclosporine, telithromycin, clarithromycin, nefazodone, and ritonavir" Named in the label: "voriconazole" Retrieved from DailyMed 2026-10-12.

Open source

FDA interaction table

FDA's example-interaction table lists Voriconazole as a strong CYP3A inhibitor, and Dronedarone as a sensitive CYP3A substrate. FDA grades the roles; the severity tier on this row is the desk's rule. Table content current as of 2026-05-29.

Open source

Open this pair in the desk

All pairs for Dronedarone · Voriconazole

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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