All pairs

Eplerenone and Ketoconazole

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)”
Inspra (eplerenone), section 4 CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Eplerenone · Ketoconazole

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.