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Eplerenone and Ritonavir

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“INSPRA is contraindicated in all patients with: … concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)”
Inspra (eplerenone), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Eplerenone · Ritonavir

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.