Eplerenone and troleandomycin

Desk tier: Avoid together

Mechanism: labeled contraindication (labeled contraindication)

“INSPRA is contraindicated in all patients with: … concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)”

Inspra (eplerenone), section 4 CONTRAINDICATIONS. DailyMed label

Why this grade

Inspra (eplerenone) label, Contraindications

The Inspra (eplerenone) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "INSPRA is contraindicated in all patients with: … concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)" Named in the label: "troleandomycin" Retrieved from DailyMed 2026-10-12.

Inspra (eplerenone) label on DailyMed

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All pairs for Eplerenone · troleandomycin

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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