Esketamine and Alprazolam

Desk tier: Serious concern

Mechanism: NMDA dissociative × CNS depressant (additive CNS depression)

“Concomitant use with CNS depressants (e.g., benzodiazepines, opioids, alcohol) may increase sedation … Closely monitor for sedation with concomitant use of SPRAVATO with CNS depressants.”

Spravato (esketamine), section 7.1 Central Nervous System Depressants; 5.1. DailyMed label

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All pairs for Esketamine · Alprazolam

Educational reference only. Not FDA-cleared. The Prescribing Information governs.