All pairs

Esketamine and Amphetamine

Desk tier: Use care

Mechanism: stacked proconvulsant effect (lowered seizure threshold)

“Concomitant use with psychostimulants (e.g., amphetamines, methylphenidate, modafinil, armodafinil) may increase blood pressure … Closely monitor blood pressure with concomitant use of SPRAVATO with psychostimulants.”
Spravato (esketamine), section 7.2 Psychostimulants; 5.7. DailyMed label

Open this pair in the desk

All pairs for Esketamine · Amphetamine

Educational reference only. Not FDA-cleared. The Prescribing Information governs.