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Esketamine and Methylphenidate

Desk tier: Use care

Mechanism: esketamine × methylphenidate (blood pressure may rise)

“Concomitant use with psychostimulants (e.g., amphetamines, methylphenidate, modafinil, armodafinil) may increase blood pressure … Closely monitor blood pressure with concomitant use of SPRAVATO with psychostimulants.”
Spravato (esketamine), section 7.2 Psychostimulants; 5.7. DailyMed label

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All pairs for Esketamine · Methylphenidate

Educational reference only. Not FDA-cleared. The Prescribing Information governs.