Fluoxetine and Methylene blue

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“Avoid concomitant use of PROVAYBLUE with selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs) and opioids.”

ProvayBlue (methylene blue injection), section Boxed Warning (Serotonin Syndrome with Concomitant Use of Serotonergic Drugs and Opioids). DailyMed label

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All pairs for Fluoxetine · Methylene blue

Educational reference only. Not FDA-cleared. The Prescribing Information governs.