Isocarboxazid and Cyclobenzaprine

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“Marplan should not be administered together with, or in close proximity to, other MAO inhibitors or dibenzazepine-related entities … Cyclobenzaprine HCL”

Marplan (isocarboxazid), section CONTRAINDICATIONS. DailyMed label

Why this grade

Marplan (isocarboxazid) label, Contraindications

The Marplan (isocarboxazid) label lists this combination under Contraindications. CONTRAINDICATIONS: "Marplan should not be administered together with, or in close proximity to, other MAO inhibitors or dibenzazepine-related entities … Cyclobenzaprine HCL" Named in the label: "Cyclobenzaprine HCL" Retrieved from DailyMed 2026-10-19.

Marplan (isocarboxazid) label on DailyMed

FDA boxed / safety communication

MAOI labels contraindicate serotonergic agents. Serotonin toxicity, hypertensive crisis.

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Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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