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Itraconazole and Dronedarone

Desk tier: Avoid together

Mechanism: moderate CYP3A4 inhibition of clearance (↑ exposure)

“Coadministration of a number of CYP3A4 substrates are contraindicated with SPORANOX®.”
Sporanox (itraconazole), section CONTRAINDICATIONS. DailyMed label

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All pairs for Itraconazole · Dronedarone

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.