Ketamine and Lorazepam

Desk tier: Serious concern

Mechanism: NMDA dissociative × CNS depressant (additive CNS depression)

“Concomitant use of ketamine with opioid analgesics, benzodiazepines, or other central nervous system (CNS) depressants … may result in profound sedation, respiratory depression, coma, and death”

Ketalar (ketamine), section 7.3 Benzodiazepines, Opioid Analgesics, Or Other CNS Depressants; 5.9. DailyMed label

Why this grade

Ketalar (ketamine) label, 7.3 Benzodiazepines, Opioid Analgesics, Or Other CNS Depressants; 5.9

The Ketalar (ketamine) label warns about this interaction: "Concomitant use of ketamine with opioid analgesics, benzodiazepines, or other central nervous system (CNS) depressants … may result in profound sedation, respiratory depression, coma, and death" Retrieved from DailyMed 2026-09-27.

Open source

PMID 31006110

2019 Clin Pharmacol Ther. 2B6 PM stacks efavirenz. Same isoform as ketamine and methadone.

Open source

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All pairs for Ketamine · Lorazepam

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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