Levoketoconazole and Midostaurin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Concomitant use of RECORLEV with other drugs that cause QT prolongation associated with ventricular arrhythmias, including torsades de pointes, is contraindicated”

Recorlev (levoketoconazole), section 7.1 Effect of RECORLEV on Other Drugs (Table 6). DailyMed label

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All pairs for Levoketoconazole · Midostaurin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.