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Linezolid and Phenelzine

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“Linezolid should not be used in patients taking any medicinal product which inhibits monoamine oxidases A or B (e.g., phenelzine, isocarboxazid)”
Zyvox (linezolid), section 4.2 Monoamine Oxidase Inhibitors. DailyMed label

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All pairs for Linezolid · Phenelzine

Educational reference only. Not FDA-cleared. The Prescribing Information governs.