All pairs

Lonafarnib and Simvastatin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“ZOKINVY is contraindicated in patients taking: … Lovastatin, simvastatin, or atorvastatin”
Zokinvy (lonafarnib), section 4 CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Lonafarnib · Simvastatin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.