All pairs

Lopinavir/ritonavir and Apalutamide

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“KALETRA is contraindicated with drugs that are potent CYP3A inducers”
Kaletra (lopinavir/ritonavir), section 4 CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Lopinavir/ritonavir · Apalutamide

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.