All pairs

Lopinavir/ritonavir and Sildenafil (PAH)

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“KALETRA is contraindicated with drugs that are highly dependent on CYP3A for clearance”
Kaletra (lopinavir/ritonavir), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Lopinavir/ritonavir · Sildenafil (PAH)

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.