All pairs

Methadone and Buprenorphine

Desk tier: Serious concern

Mechanism: partial μ-agonist × full agonist (precipitated withdrawal)

“May reduce the analgesic effect of methadone hydrochloride tablets and/or precipitate withdrawal symptoms. … Avoid concomitant use.”
Methadone HCl tablets, section 7 DRUG INTERACTIONS (Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics). DailyMed label

Open this pair in the desk

All pairs for Methadone · Buprenorphine

Educational reference only. Not FDA-cleared. The Prescribing Information governs.