Methadone and Carbamazepine

Desk tier: Serious concern

Mechanism: strong CYP2B6 induction of clearance (↓ exposure / loss of efficacy)

“The concomitant use of methadone hydrochloride tablets and CYP3A4, CYP2B6, CYP2C19, or CYP2C9 inducers can decrease the plasma concentration of methadone”

Methadone HCl tablets, section 7 DRUG INTERACTIONS (Inducers of CYP3A4, CYP2B6, CYP2C19, or CYP2C9). DailyMed label

Open this pair in the desk

All pairs for Methadone · Carbamazepine

Enzyme behind this pair: CYP2B6

Educational reference only. Not FDA-cleared. The Prescribing Information governs.