Methadone and Ethanol

Desk tier: Serious concern

Mechanism: alcohol × CNS depressant (additive CNS depression)

“Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.”

Methadone HCl tablets, section Boxed Warning (Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants); 5.3. DailyMed label

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All pairs for Methadone · Ethanol

Educational reference only. Not FDA-cleared. The Prescribing Information governs.