Methadone and Fluconazole

Desk tier: Serious concern

Mechanism: methadone QT stack (additive QT prolongation / TdP)

“The concomitant use of methadone hydrochloride tablets with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors … could cause potentially fatal respiratory depression”

Methadone HCl tablets, section Boxed Warning (Cytochrome P450 Interaction); 7 DRUG INTERACTIONS. DailyMed label

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All pairs for Methadone · Fluconazole

Educational reference only. Not FDA-cleared. The Prescribing Information governs.