Methadone and Gabapentin

Desk tier: Serious concern

Mechanism: gabapentinoid × opioid (respiratory depression)

“Profound sedation, respiratory depression, coma, and death may result from the concomitant use of methadone hydrochloride tablets with benzodiazepines and/or other CNS depressants … gabapentinoids”

Methadone HCl tablets, section 5.3 Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants (see Boxed Warning). DailyMed label

Open this pair in the desk

All pairs for Methadone · Gabapentin

Educational reference only. Not FDA-cleared. The Prescribing Information governs.