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Methadone and Ondansetron

Desk tier: Serious concern

Mechanism: methadone QT stack (additive QT prolongation / TdP)

“The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome”
Methadone HCl tablets, section 7 DRUG INTERACTIONS (Serotonergic Drugs); 5.9. DailyMed label

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All pairs for Methadone · Ondansetron

Educational reference only. Not FDA-cleared. The Prescribing Information governs.