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Methadone and Zidovudine

Desk tier: Use care

Mechanism: methadone raises zidovudine exposure (higher zidovudine exposure)

“Experimental evidence demonstrated that methadone increased the AUC of zidovudine, which could result in toxic effects.”
Methadone HCl tablets, section 7 DRUG INTERACTIONS (Effects of Methadone on Antiretroviral Agents). DailyMed label

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All pairs for Methadone · Zidovudine

Educational reference only. Not FDA-cleared. The Prescribing Information governs.