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Mifepristone and Simvastatin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“KORLYM is contraindicated in: … Patients taking drugs metabolized by CYP3A such as simvastatin, lovastatin”
Korlym (mifepristone), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Mifepristone · Simvastatin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.