All pairs

Naloxegol and Clarithromycin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“MOVANTIK is contraindicated in: … Patients concomitantly using strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole)”
Movantik (naloxegol), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Naloxegol · Clarithromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.