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Phenelzine and Methadone

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“The use of methadone hydrochloride tablets is not recommended for patients taking MAOIs or within 14 days of stopping such treatment.”
Methadone HCl tablets, section 7 DRUG INTERACTIONS. DailyMed label

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All pairs for Phenelzine · Methadone

Educational reference only. Not FDA-cleared. The Prescribing Information governs.