Pimozide and Clarithromycin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“pimozide is contraindicated in patients receiving the macrolide antibiotics clarithromycin, erythromycin, azithromycin, dirithromycin, and troleandomycin.”

Pimozide tablets, section CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Pimozide · Clarithromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.