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Pimozide and Fluoxetine

Desk tier: Avoid together

Mechanism: strong CYP2D6 inhibition of clearance (↑ exposure)

“The use of PROZAC is contraindicated with the following: Pimozide”
Prozac (fluoxetine), section 4.2 Other Contraindications. DailyMed label

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All pairs for Pimozide · Fluoxetine

Enzyme behind this pair: CYP2D6

Educational reference only. Not FDA-cleared. The Prescribing Information governs.