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Pimozide and Ketoconazole

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“pimozide is contraindicated in patients receiving the azole antifungal agents itraconazole and ketoconazole.”
Pimozide tablets, section CONTRAINDICATIONS. DailyMed label

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All pairs for Pimozide · Ketoconazole

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.