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Pimozide and Paroxetine

Desk tier: Avoid together

Mechanism: strong CYP2D6 inhibition of clearance (↑ exposure)

“Concomitant use of pimozide with paroxetine and other strong CYP 2D6 inhibitors is contraindicated”
Pimozide tablets, section CONTRAINDICATIONS. DailyMed label

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All pairs for Pimozide · Paroxetine

Enzyme behind this pair: CYP2D6

Educational reference only. Not FDA-cleared. The Prescribing Information governs.