Pimozide and Sertraline

Desk tier: Avoid together

Mechanism: weak CYP2D6 inhibition of clearance (↑ exposure)

“Concomitant use of pimozide in patients taking sertraline is contraindicated”

Pimozide, section CONTRAINDICATIONS. DailyMed label

Why this grade

Pimozide label, Contraindications

The Pimozide label lists this combination under Contraindications. CONTRAINDICATIONS: "Concomitant use of pimozide in patients taking sertraline is contraindicated" Named in the label: "sertraline" Retrieved from DailyMed 2026-10-12.

Open source

FDA interaction table

FDA's example-interaction table lists Sertraline as a weak CYP2D6 inhibitor, and Pimozide as a moderately sensitive CYP2D6 substrate. FDA grades the roles; the severity tier on this row is the desk's rule. Table content current as of 2026-05-29.

Open source

PMID 25974703

2015 Clin Pharmacol Ther. CPIC SSRIs. Flip 2C19 on this desk for citalopram / escitalopram.

Open source

Open this pair in the desk

All pairs for Pimozide · Sertraline

Enzyme behind this pair: CYP2D6

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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